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71.
抗体阴性重症肌无力发病与凝集素之间关系研究 总被引:2,自引:0,他引:2
借助研究抗体阴性重症肌无力(MG)发病与凝集素之间的关系,以阐明其发病过程是否与凝集素有关。方法观察伴刀豆球蛋白A(ConA)和麦胚凝集素(Triticum)及其凝集素-糖复合物对TE671细胞表达的乙酰胆碱受体(AChR)功能的作用,以及对α-BuTx结合试验的影响。结果有两种凝集素对AChR功能均有抑制作用,抑制率(%)分别为54±14(n=11)和47±16(n=10),此作用可被3种糖抑制,抑制率(%)分别为:95±5(n=5)和84±8(n=5);69±6(n=4)和65±5(n=4);39±4(n=5)和57±6(n=5);ConA抑制α-BuTx结合试验,而Triticum则不能。结论Triticum和抗体阴性MG患者非IgG部分对AChR功能和α-BuTx结合试验的作用类同或一致,表明抗体阴性MG患者非IgG部分中的内源性Triticum样糖蛋白在其发病过程中起重要作用。 相似文献
72.
73.
孕马血清经偏磷酸、乙醇分级沉淀得比活为409IU/mg的粗品,回收率为47.3%。粗品经离子交换层析得到比活为1455IU/mg的精品,回收率达97.4%。再过柱层析得比活为2400IU/mg的产品。 相似文献
74.
131I治疗甲亢性心脏病105例分析 总被引:6,自引:0,他引:6
目的 探讨甲亢性心脏病的临床特征、发病相关因素及其治疗方案。方法 对105例甲亢性心脏病患者的临床资料进行回顾性分析。结果 ①甲亢性心脏病患者以中老年女性为主,心律失常以心房纤颤常见;②甲状腺结节性肿大的甲亢患者伴发甲亢性心脏病的几率高于弥漫性肿大的患者;③经^131I抗甲亢治疗以后,随着甲亢的治愈大多数甲亢性心脏病可以治愈。结论 甲亢性心脏病患者的临床特征以心房纤颤、心力衰竭为主,其发病与甲状腺肿大类型有一定的关系,而^131I治疗对甲亢性心脏病的治疗效果非常理想。 相似文献
75.
Hideki Aragane Hideki Fujii Takaharu You Atuhiro Morita Morimichi Miyazaki Kiyoshi Morita Tohru Ohkawara Shinji Fukumitu Yoshihiko Sawa Yasuo Ohkawara 《Nihon Shokakibyo Gakkai zasshi》2006,103(5):537-542
This report describes our experience with a 60 year old male who suffered from a recrudescence of groove pancreatitis. He had been treated by conservative medication therapy by proton pump inhibitor used for therapy of duodenal ulcer, and was in remission. During a follow-up one year later, endoscopy revealed gastric cancer, for which a proximal gastrectomy and vagotomy were performed. The patient continues to remain in remission for the groove pancreatitis. Our experience with the clinical course of this disease, in which treatment for duodenal ulcer was used effectively, offers new insights into the progression and therapy of groove pancreatitis. 相似文献
76.
Cellular changes were immunocytochemically characterized in skin vessels of five patients with idiopathic generalized racemose livedo (Sneddon's syndrome), and one patient with localized racemose livedo associated with essential thrombocythaemia. Antibodies against α-smooth muscle-actin, tropomyosin, desmin, vimentin, factor VIII-related antigen, human endothelial cells (CD31), human macrophages (CD68), and HLA-DR positive cells (CR3/43) were used. Conventional light microscopy showed, in all cases, intimal thickening of ascending arteries and arterioles as a result of an accumulation of cells and extracellular hyalinized material. None of the specimens showed infiltration with polymorphonuclear leucocytes or macrophages. The cells in the region of the intimal hyperplasia showed intense positive immunostaining for α-smooth muscle actin and tropomyosin. Staining for the intermediate filament desmin was localized to the resident smooth muscle cells of the media, whereas staining for vimentin was found in all types of cells in both the intima and media. Positive immunostaining for factor VIII-related antigen and CD31 was strictly confined to the endothelial cells lining the narrowed lumina of the vessels. No positive staining with either antibody was observed in totally occluded vessels. Cells in the subintimal space did not show reactivity for CD68 in any of the specimens, but two cases showed solitary cells with positive staining for HLA-DR in this region. There were no differences in staining pattern between Sneddon's syndrome and essential thrombocythaemia with any of the antibodies. Our results support the assumption that the ‘intimal proliferation’ in both diseases is caused by colonization of the subendothelial space with contractile cells of possibel smooth muscle origin. The similarities in histopathology and immunocytochemistry might indicate that in both diseases platelet-derived factors play a causative role. 相似文献
77.
未研究发现,经热休克处理的大鼠注油酸后,肺组织损伤明显减轻,Western印迹分析显示热休克使大鼠肺组织中HSP70含量明显增多;Northern印迹分析证实此乃由于HSP70mRNA转录增加所致。说明热休克处理使肺组织HSP70基因表达增强;提示热休克反应对大鼠油酸肺的保护作用与肺组织细胞中HSP70基因表达增强及与HSP70增多有关。 相似文献
78.
True fibromas develop as painless slow-growing nodular tumours. They may appear in any portion of the nail apparatus. The clinical features vary according to their anatomical site. In contrast, the histological features, consisting of a dermal hypocellular reticular nodule with ill-defined demarcation, were similar in all our patients, and factor XIIIa was negative. 相似文献
79.
Jyh-Pyng Gau Chih-Cheng Chen Hui-Chi Hsu Chao-Hung Ho Wing-Keung Chau Jie-Yu You Yuan-Bin Yu 《Blood coagulation & fibrinolysis》2006,17(1):53-56
Nucleotide 6724 of the factor VIII gene harbors a polymorphism of low frequency. A report from Taiwan claimed that 97.9% of the 83 alleles examined were of the A nucleotide at this position, which is quite different to the data from Western populations. Furthermore, this nucleotide is the start of exon 25, located in juxtaposition to the splicing acceptor of intron 24. We wonder if the nucleotide change at this location might have any effect on the splicing process of pre-mRNA. Using genomic DNA with direct sequencing of the polymerase chain reaction-amplified intron 24/exon 25 junction site, we found that 59 of the 60 patient samples were of the GTG sequence at nucleotides 6724-6726. The polymorphism is similar between populations in Taiwan and Western countries. The sequence of intron 24 around the splicing acceptor was always TCCAACTCTATTGCCCTCAG (-20 to -1), except for one hemophiliac patient who had a mutation in which the absolute consensus AG doublet of the intron 24 splicing acceptor changed to the AA dinucleotide. Owing to the mutation, exon 24 was erroneously spliced to exon 26, and exon 25 was skipped. This finding further testifies to the importance of the invariant AG dinucleotide in the example of the factor VIII gene. 相似文献
80.
目的:探讨奎的平、氯氮平对精神分裂症的疗效及副作用。方法:80例患者随机分为两组,分别应用奎的平或氯氮平治疗6周,采用四级临床疗效评定标准、阳性症状与阴性症状量表(PANSS)、副反应量表(TESS)评定疗效及副反应。结果:奎的平组有效率87.5%,氯氮平组有效率82.5%。治疗第一周末,奎的平组PANSS量表总分较治疗前差异有显著性(P<0.05)。奎的平组副反应低于氯氮平组。结论:奎的平与氯氮平疗效相似,但奎的平起效较快,副反应较轻。 相似文献